Conversely, ANXA1 overexpression increased GOT1-related metabolite levels and enhanced glutamine uptake, knockdown of GOT1 can weaken this ability in vivo and in vitro (Supplementary Fig. S4F-G), thereby supplying essential precursors for tumor biosynthesis and maintaining energy homeostasis, further increasing the resilience of tumor cells to oxidative stress (Supplementary Fig. S4H).Therefore, cell experiments have shown that knocking down or overexpressing ANXA1 can reduce GSH or increase ROS levels, while overexpression or knocking down GOT1 can reverse this change. Here, GOT1 is linked to neoplasm.