In ANXA1-knockdown cells, the levels of aspartat and glutamate were significantly reduced compared to controls, overexpression of GOT1 in ANXA1 knockdown cells reversed the stabilizing effect of ANXA1 knockdown on GOT1, a trend also observed in the xenograft tumor model (Fig. 5H and Supplementary Fig. S4E). The gene discussed is GOT1; the disease is neoplasm.