NEK1 and amyotrophic lateral sclerosis: We studied NEK1’s genetic contribution to ALS pathogenesis by analyzing the WES data from 920 Korean patients with ALS and identifying 16 NEK1 variants in 23 patients (23/920, 2.5%), including two novel frameshift variants (p.E853Rfs*9, n=4; p.D1112Efs*50, n=1), one initiation codon variant (p.M1?, n=1), one splicing variant of the consensus splice site (c.3222+1G>A, n=1), one synonymous splicing variant (p.Q132=, n=2), two splicing variants, and ten missense variants (Fig. 1A and Table S1).