In this context, it is worth noting that, whereas the tumor suppressive activity of RNASET2 has been widely demonstrated both in vitro and in vivo across numerous cell lines representing a wide range of human cancer types, the few cell lines that turned out to be unresponsive to RNASET2-mediated suppression represented highly aggressive cancer subtype, in which most or all pathways involved in the highly pleiotropic oncosuppressive role of RNASET2 have likely been inactivated. This evidence concerns the gene RNASET2 and neoplasm.