RNASET2 and neoplasm: We also demonstrated that overexpression of murine Rnaset2 in a colon syngeneic mouse carcinoma model increased the intra-tumor M1/M2 macrophage ratio, activated T cells, delayed tumor growth, and led to tumor rejection, further confirming and extending the role of T2 RNases as immune-modulators in anti-tumor immune response [17].