To test the possible correlation between RNASET2 levels and macrophage polarization in human prostate cancer tissue samples, we interrogated the TCGA dataset, using the publicly available portal TIMER2.0; This analysis showed a statistically significant, though moderate, direct correlation between RNASET2 levels and M1 macrophage infiltration in PCa patients. The gene discussed is RNASET2; the disease is prostate carcinoma.