RNASET2 and cancer: Based on previous studies on the oncosuppressive activities of RNASET2 in different cancer types [7, 9, 13, 24], and deregulated expression of this gene in PCa, we investigated the potential cell autonomous and non-cell autonomous effects of RNASET2 in vitro and in vivo, using two well-establishedestablished PCa in vitro models, namely PC-3 and- 22Rv1 cells, selected base on their differential degrees of aggressiveness and clinical relevance, representing early-stage and advanced disease, respectively [41].