These findings are consistent with our previous work in a syngeneic C51 colon carcinoma model, where murine RNASET2 overexpression delayed tumor growth and promoted recruitment of M1-like macrophages, suppression of M2-like macrophages and myeloid-derived suppressor cells (MDSCs), and expansion of CD8+ T cells [17]. The gene discussed is CD8A; the disease is colon carcinoma.