Our findings also showed that BIRC2 plays a crucial role in cellular apoptosis as well as cell growth and motility, suggesting that CITED4-mediated BIRC2 expression promotes cancer cell malignancies by inhibiting the apoptotic pathway and activating oncogenic properties; thus, the CITED4-BIRC2 axis represents a potential regulator of drug resistance in PC. Here, CITED4 is linked to pachyonychia congenita.