Accordingly, tamoxifen-induced deletion of COP1 E3 ubiquitin ligase at ~ 2-mo of age resulted in increased expression of microglial genes involved in IFN signalling and APOE, a major AD risk factor gene, at 22-mo transgenic C57BL/6N mice, compared to WT mice (Ndoja et al. 2020). This evidence concerns the gene APOE and Alzheimer disease.