Moreover, SAF-AuNPs/DOX-AuNPs combination showed a significant decrease in hepatic MMP-9 level as compared to the HCC group (p < 0.001) and (p < 0.01) as compared to SAF-AuNPs and (p < 0.001) compared to DOX-AuNPs (Fig. 10a). The gene discussed is MMP9; the disease is hepatocellular carcinoma.