In addition, DOX-AuNPs revealed 36.67% (p < 0.001) and 81.25% (p < 0.001) significant elevation in albumin and total protein levels, respectively, as compared to HCC group and 36.79% (p < 0.001) significant elevation in total protein level as compared to DOX group. This evidence concerns the gene ALB and hepatocellular carcinoma.