PLA2G7 and silicosis: Flow cytometry analysis of lung-infiltrating macrophages revealed a reduction in profibrotic SiglecFloAM subsets in CreLyz2Pla2g7flox/flox mice compared with those in Pla2g7flox/flox mice, indicating a crucial role for Pla2g7 in modulating macrophage function and its contribution to silicosis-induced fibrosis (Fig. 4f, g).