We found that silencing Alcat1 did not affect PINK1 expression in the mitochondria of Pla2g7-overexpressing macrophages, indicating that CL-related mitochondrial autophagy pathways are influenced by Lp-PLA2 levels in silicosis, via PINK1/Parkin-dependent and PINK1/Parkin-independent pathways. The gene discussed is PRKN; the disease is silicosis.