Next, we compared M3258 with Btz, and tested whether Btz and M3258 synergize in this model because we found that Btz and M3258 synergize in vitro in ALL cell lines (Supplementary Fig. S2a) and that ONX-0914 and Btz synergize in xenograft models of MM22. Here, CASC3 is linked to acute lymphoblastic leukemia.