A recent study has found that 25 Hz repetitive transcranial magnetic stimulation alleviates glutamate excitotoxicity and upregulates the expression of glutamate transporter-1 (GLT-1) by activating phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) in 3xTg AD mice [10]. This evidence concerns the gene SLC1A2 and Alzheimer disease.