PRKCG and ischemic stroke: TAT-M2PBM, a peptide that disrupts TRPM2-protein kinase C γ (PKCγ), a cell-permeable peptide that disrupts TRPM2-PKCγ coupling, significantly inhibits eNMDARs-mediated excitotoxicity and produces potent protection against ischemic stroke in vitro and in vivo [79].