Induced NUP98::KDM5A degradation caused significant morphological changes in AML cells that are characteristic of terminal myeloid differentiation (Fig. 2G), including loss of the progenitor marker c-Kit and an increase of the myeloid differentiation markers Mac-1 and Gr-1 (Fig. 2H–J). The gene discussed is KDM5A; the disease is acute myeloid leukemia.