Finally, transcription factor motif analysis revealed that consensus motifs of GATA- and AP1-families were enriched in genomic regions with high accessibility in NUP98::KDM5A AML, while binding sites for ETS and IRF transcription factors were enriched in regions that were less accessible in NUP98::KDM5A-expressing cells (Supplementary Fig. 1F). Here, TRIM63 is linked to acute myeloid leukemia.