Finally, the direct NUP98::KDM5A target genes were significantly overexpressed in NUP98::KDM5A-expressing AML cells compared to control cells that only express the NUP98 N-terminus and NrasG12D10 and were highly expressed in samples of NUP98::KDM5A AML patients (Fig. 4H, I). The gene discussed is KDM5A; the disease is acute myeloid leukemia.