Proliferation of murine AML cell lines driven by the KMT2A::MLLT3 fusion (RN2)54 and N-terminal Cebpa mutations (Cebpap30/p30)55 was also dependent on CDK12, suggesting CDK12 is a broad AML dependency, in line with a previous report56 (Supplementary Fig. 6B, C). This evidence concerns the gene CDK12 and acute myeloid leukemia.