ATAC-seq and RNA-seq analysis of dTAG-NUP98::KDM5A cells revealed a strong correlation of chromatin accessibility and gene expression with NUP98::KDM5A AML patient data (Supplementary Fig. 2G), further substantiating the clinical relevance of our mouse model for the analysis of the human disease. This evidence concerns the gene KDM5A and acute myeloid leukemia.