The immuno-phenotype of leukemic blasts from the BM, spleen and blood of recipient mice was similar to previously established murine NUP98::KDM5A models10, showing moderate levels of c-Kit and high levels of Mac-1 and Gr-1 surface markers, confirming the myeloid origin of the leukemia (Supplementary Fig. 2E, F). Here, NUP98 is linked to leukemia.