Indeed, by performing CUT&Tag (Cleavage Under Targets and Tagmentation) for H3K27ac and H3K4me3 marks in blasts from a NUP98::KDM5A patient-derived xenograft (PDX) AML model, we found that the majority of the 1921 genomic regions that are specifically accessible in NUP98 fusion-driven AML also showed overlapping H3K27ac and H3K4me3 marks (Fig. 1D). The gene discussed is KDM5A; the disease is acute myeloid leukemia.