To clarify whether adipocyte OGT was associated with hematopoietic abnormalities in obesity, we first conducted a peripheral CBC analysis, and found that WBC count was significantly reduced in the HFD-OGT-AKO group compared to the HFD-WT group, with no statistical change observed in RBC or PLT (Fig. 3H and Supplementary Fig. 3H, I). Here, OGT is linked to obesity due to melanocortin 4 receptor deficiency.