Taken together, our findings strongly suggest that for 30/32 BCA cases (93.7%), activation of the Wnt/β-catenin signalling pathway, either through mutation of CTNNB1 at p.I35T or FBXW11 at p.F517S (Fig. 7) is the primary mechanism of tumourigenesis in this tumour entity. This evidence concerns the gene FBXW11 and neoplasm.