CYLD and adnexal spiradenoma/cylindroma of a sweat gland: Patients with Brooke-Spiegler syndrome, a rare, inherited condition attributed to germline disruptive variants in the CYLD gene, develop tumours primarily on the face, scalp and neck, with cylindromas, spiradenomas and trichoepithelioma as the most common presentation, and rarely, SGTs52,53.