CXCL8 and neoplasm: While previous studies have established the tumor-suppressive function of DACH1 in different cancer types, such as its ability to inhibit cyclin D1 expression to restrict renal cancer cell growth [10], or its role in antagonizing CXCL8 to suppress tumor development and enhance prognosis in lung adenocarcinoma [11], the findings of this study indicate that DACH1 may function as a tumor promoter in CRC.