Altogether, this comparative analysis suggests that most FUS-ALS dysregulated processes are due to FUS GOF and include metabolic pathways e.g., downregulation of aerobic respiration, oxidative phosphorylation, and mitochondrial respiratory chain complex assembly, regulation of RNA metabolism e.g., upregulation of mRNA 3’ end processing, regulation of RNA splicing, regulation of mRNA processing, RNA localization, and RNA export from nucleus. Here, FUS is linked to amyotrophic lateral sclerosis.