In contrast to PARADIGM‐HF, DAPA‐HF, and EMPEROR‐Reduced, DIGIT‐HF did not require fulfilled B‐type natriuretic peptide (BNP)/N‐terminal proBNP (NT‐proBNP) and renal function (estimated glomerular filtration rate [eGFR]) criteria for patient inclusion. This evidence concerns the gene NPPB and hydrops fetalis.