These criteria include the following items: First, a diagnosis of TSC can be confirmed by pathogenic mutations in the TSC1 or TSC2 gene; second, in order to prove a clinical diagnosis of TSC, it is necessary to have 2 main features or 1 main feature and 2 secondary features at the same time; and third, it is possible to suspect that 1 main feature or 2 secondary features indicate TSC.[13]. Here, TSC1 is linked to tuberous sclerosis.