SLC6A3 and Hyperbilirubinemia: DAT positivity has been demonstrated to be a standard indicator among ABO incompatible births.[17] However, DAT positivity alone does not always predict severe hyperbilirubinemia and does not have sufficient strength to indicate the need for PT.[18,19] On the other hand, Tiras et al[20] conducted a comparative clinical study exploring the predictive value of COHb over the DAT, and they concluded that cord blood COHb levels did not show a significant alteration and suggested the DAT as a more valid method in risk prediction of neonatal hyperbilirubinemia.