Early elevation of serum thyroglobulin (Tg)[33] and preexisting Tg autoimmunity have been linked to PD-1 inhibitors–induced destructive thyroiditis.[34] Baseline thyroglobulin antibody (TgAb) or TPOAb positivity and irregular thyroid ultrasound findings are considered potential risk factors for ICI-TD,[32,35–37] though the role of these antibodies remains debated. The gene discussed is PDCD1; the disease is Autoimmunity.