Cell-mediated cytotoxicity appears to have no significant impact on α cells and exocrine glands.[17] Intriguingly, although glucagon levels remain stable, α cell responsiveness appears reduced.[24] Elevated lipase and amylase in 2 ICI-DM patients[7,19] suggest possible exocrine involvement, and some studies have reported antibodies against exocrine enzymes.[48] However, nonspecific enzyme elevation without diabetes has also been observed. The gene discussed is GCG; the disease is diabetes mellitus.