INS and diabetes mellitus: The following requires clinical attention: although ICI-induced DKA mostly presents with gastrointestinal symptoms, some patients may exhibit only polyuria, thirst, fatigue, agitation, or blurred vision but still develop severe DKA.[1,16,22,26] Additionally, ICI-DM can sometimes be difficult to control, with patients experiencing recurrent DKA even under insulin management.[1,26]