HCMV infection elicits a robust cell-mediated immune response, characterized by sequential activation of natural killer cells followed by adaptive immune components, including high-affinity neutralizing antibodies, CD4+/CD8+ T cells, and B cells.[17–19] Despite this comprehensive immune activation, HCMV establishes lifelong persistence through sophisticated immune evasion strategies. This evidence concerns the gene CD4 and cytomegalovirus infection.