Current studies indicate that mutations, abnormal expression levels, or functional impairments in the CACNA2D3 gene are closely linked to various diseases including neurological disorders,[36] cancers,[37] and type 2 diabetes.[38] Furthermore, GeneMANIA analysis reveals that ANO6 activity primarily involves chloride ion transport through gating mechanisms. This evidence concerns the gene CACNA2D3 and type 2 diabetes mellitus.