IGFALS, a critical regulator of growth factor bioavailability and cellular metabolism,[23] demonstrates tumor-suppressive properties in hepatocellular carcinoma.[24] Our MR analyses reveal a novel protective association between genetically predicted IGFALS levels and GC risk, marking the first evidence of its potential antineoplastic role in gastrointestinal malignancies. Here, IGFALS is linked to hepatocellular carcinoma.