CCDC80 and cancer: CCDC80, encoding a secreted protein containing the P-DUDES domain, regulates peroxide metabolism and tumor-suppressive signaling.[18] Targeted proteomic profiling demonstrates elevated plasma CCDC80 levels in GC patients versus healthy controls (AUC = 0.87, 95% CI = 0.79–0.94), supporting its diagnostic potential.[19] Mechanistically, CCDC80 mediates extracellular matrix remodeling and cell adhesion while exhibiting pan-cancer inhibitory effects: validated in colon,[20] pancreatic/thyroid,[21,22] and ovarian cancers.