PDCD1LG2 and neoplasm: Liu et al demonstrated PDCD1LG2 overexpression enhances CD8+ T-cell infiltration and cytotoxicity in murine GC models,[26] while another study found PDCD1LG2-expressing tumor cells activate T-cell lymphokine production via specific antigen presentation modes.[27] This functional duality underscores its complex immunomodulatory mechanisms.