In addition, LBP was significantly positively correlated with TG, FBG, and IR.[52] Furthermore, in a cross-sectional study on the independent correlation between LBP levels and liver fat fraction and liver volume in 99 adolescents with obesity showed that LBP levels can be used as biomarker for predicting high NAFLD risk in adults.[53] Previous epigenetic studies conducted in LBP knockout NAFLD animal models demonstrated decreased inflammation (characterized by decreased levels of IL-6, TNF-ɑ), intensified lipid accumulation, and more severe NAFLD. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.