IFNG and gout: The meta-analysis revealed that an elevated risk of gout was significantly associated with increased levels of CXC motif chemokine ligand 9 (CXCL9), also known as monokine induced by gamma interferon (MIG), with an OR of 1.12 (95% CI: 1.02–1.24; P = .020), based on the IVW method after combining the MR results from both datasets (Fig. 8).