Reverse MR analysis revealed a suggestive positive association between gout and CXC motif chemokine ligand 1 (CXCL1) (OR = 1.127; 95% CI: 1.014–1.253; P = .027), interleukin-1 receptor antagonist (IL-1Ra) (OR = 1.102; 95% CI: 1.004–1.210; P = .042), and TNF-α (OR = 1.124; 95% CI: 1.026–1.232; P = .012) (Fig. 5). This evidence concerns the gene TNF and gout.