The Fibroblast Growth Factor (FGF) family comprises structurally homologous polypeptides that orchestrate fundamental biological processes including cellular proliferation, differentiation, and metabolic homeostasis.[40,41] Of pathophysiological relevance, FGF21 has emerged as a pleiotropic metabolic modulator exhibiting context-dependent duality in gout pathogenesis. This evidence concerns the gene FGF21 and gout.