CXCL8 and Erythema: These factors interact synergistically, facilitating the recruitment and activation of neutrophils, thereby exacerbating inflammation and ultimately resulting in the clinical manifestations of acute gout attacks, such as severe joint pain, swelling, and erythema.[36,37] The association of IL-1β, TNF-α IL-6, and IL-8 with gout has been well-established.