Mitochondrial dysfunction has increasingly been linked to neuropsychiatric disorders,73,74 which often exhibit structural changes in neurons, such as dendritic atrophy and spine loss.75,76 Recent evidence further supports a strong link between mitochondrial dynamics and psychiatric conditions, including anxiety and depression.14,77 For instance, high-anxiety animal models show reduced mitofusin 2 levels specifically in medium spiny neurons of NAc, leading unexpectedly to larger, rounded mitochondria rather than the smaller, fragmented structures typically associated with impaired fusion. This evidence concerns the gene MFN2 and major depressive disorder.