Since COVID-19 caused by SARS-CoV-2 from the Omicron sublineages is less severe, either by viral mutations or blunting by pre-existing immunity, we propose to continue the strategy of administering an annual updated booster vaccine to PWH with a CD4+ T-cell count < 200 cells per μL, particularly in the case of discontinuing the yearly booster vaccine for all PWH. Here, CD4 is linked to COVID-19.