Hence, we aimed to assess the combined impact of SeNPs and Flutamide on the growth and programmed cell death, as well as the expression of various genes such as SNAIL, KLK3, E-cadherin, and apoptotic genes in three types of prostate cancer cells: LNCaP, PC3, and DU145. The gene discussed is SNAI1; the disease is Familial prostate cancer.