We noticed that treatment with GYY4137 specifically reversed the effect of SARS-CoV-2-HK infection on the expression of genes associated with the oxidoreductase activity (e.g., mthfr, acads, sc5d, hsd17b7, cbr4, msmo1, and me1) and Nrf2- antioxidant pathway (Figs 3I and S3B). Here, MTHFR is linked to infection.