In the multivariate logistic regression model incorporating age, uMCP-1, uVCAM-1, u-β2MG, u-IgG, and u-ALB, the results exposed that after adjusting for age, uMCP-1 was significantly associated with the incidence of LN (uMCP-1, OR = 6.99, 95% CI 1.19–41.131, P = 0.031;). The gene discussed is ALB; the disease is lobular neoplasia.