Univariate Cox proportional hazards regression analysis identified several clinical, laboratory, radiologic and demographic factors significantly associated with the risk of complicated diverticulitis, including VFA (HR: 1.005, p = 0.0009), SFA (HR: 0.998, p = 0.0061), V/S ratio (HR: 3.40, p = 0.0002), CRP (HR: 1.021, p < 0.0001), WBC count, neutrophil metrics, procalcitonin, bilirubin levels, male gender, age ≥ 60, multiple episodes of diverticulitis, and sigmoid colon localization (Table 6). This evidence concerns the gene CRP and diverticulitis.