LRP1 and trisomy 21: Similarly, we also identified that LRP1 (Prolow-density lipoprotein receptor-related protein 1), ATOX1 (Copper transport protein ATOX1), and EIF4E (Eukaryotic translation initiation factor 4E) were elevated in DSAD compared with both HA and EOAD controls, indicating that their upregulation is likely to be driven by trisomy 21.