Our study outcomes were: (1) Effect of OL-HDF on routine CKD MBD biomarkers; (2) Effect of OL-HDF on FGF-23, Klotho and bone turnover biomarkers; and (3) Effect of OL-HDF clinically on dry weight, height and z-scores, and change of medication doses. The gene discussed is FGF23; the disease is chronic kidney disease.