RBFOX3 and Cognitive impairment: In adult rats, folic acid increased hippocampal neurogenesis in a dose-dependent manner.113 Separately, in a rat model of cerebral ischemia, folic acid reversed ischemia-related cognitive impairment on the Y-maze.114 Moreover, hippocampal neurogenesis was robustly increased, indicated by cells double-positive for BrdU and the neuronal marker NeuN (BrdU+NeuN+).