The study on folate by Zhang et al. suggested that Notch signaling may be involved, as protein levels of Notch1, Hes1, and Hes5 were further increased in a rat model of ischemia treated with folic acid supplementation,114 while amino acid theanine treatment elevated mTOR signaling proteins, purportedly involved in neural proliferation and adult neurogenesis.107. Here, HES1 is linked to ischemia.