HES5 and ischemia: The study on folate by Zhang et al. suggested that Notch signaling may be involved, as protein levels of Notch1, Hes1, and Hes5 were further increased in a rat model of ischemia treated with folic acid supplementation,114 while amino acid theanine treatment elevated mTOR signaling proteins, purportedly involved in neural proliferation and adult neurogenesis.107