As shown in Figure 3A,B, the colitis group exhibited a significant elevation in colon SPHK and S1P content by 4.46‐fold (F = 582.9, p < 0.0001) and 5.11‐fold (F = 1755, p < 0.0001), respectively, compared to the normal control group. The gene discussed is SPHK1; the disease is colitis.