As shown in Figure 3E,F, the colitis group exhibited a marked reduction in colon Nrf2 and HO‐1 levels by 79.96% (F = 128.2, p < 0.0001) and 73.11% (F = 141.7, p < 0.0001), respectively, compared to the normal control group. The gene discussed is HMOX1; the disease is colitis.