Significant differences were observed in variables, such as age, treatment duration, serum albumin, aspartate transaminase (AST), total bilirubin (TBil), blood urea nitrogen (BUN), cystatin C (CysC), serum creatinine (Scr), creatinine clearance (Ccr), glomerular filtration rate (eGFR), hepatic and renal impairment in patients with and without anemia (P < 0.05). This evidence concerns the gene ALB and anemia (phenotype).