Validation at the protein level in prostate cancer cells confirmed a correlation between FUT8 and levels of insulin‐like growth factor binding protein‐5 (IGFBP5) (which is linked to prostate cancer progression [94]), interleukin 1 beta (IL1B) (a cytokine linked to an immune suppressive microenvironment [95]) and Prostaglandin E synthase 3 (PTGES3) (an AR regulator that promotes cell proliferation [96]) (Figure 5D–F). The gene discussed is IGFBP5; the disease is Familial prostate cancer.