FDW028 is highly selective small‐molecule inhibitor of FUT8 identified through virtual screening and chemical refinement to bind the GDP‐fucose pocket that exhibits potent anti‐tumour activity by defucosylation, has demonstrated in vivo efficacy when applied locally near tumours, and can prolong the survival of mice with metastatic colorectal cancer [110, 111]. This evidence concerns the gene FUT8 and metastatic colorectal cancer.