FUT8 maintains high expression and protein stability of immune checkpoint molecules (including PD1, PDL1, PDL1 and B7H3) meaning there is a functional link between FUT8 activity and the suppressive state of the tumour microenvironment [46, 118, 120], and FUT8 is now a central target for cancer immunotherapy [91]. The gene discussed is CD274; the disease is neoplasm.