Moderate positive correlations were observed between the SARS-CoV-2 S2 and HCoV-229E (Spearman r = 0.5153 and P = 0.010, Fig. 6A) and HCoV-OC43 (Spearman r = 0.4793 and P = 0.010, Fig. 6B) spike FcγRIIIa-binding antibody responses in those individuals with presumed or documented recent eCoV infections. Here, FCGR3A is linked to infection.