MRC-5, MRC-9, and TIG-1 fibroblast cell death induced by live Mtb bacilli 2 days after infection was specifically inhibited by VX-765, an inhibitor of caspase-1/4, and MCC950, an inhibitor of NLRP3 inflammasome, but not by PAC-1, a caspase-3 inhibitor, and z-LEHD-fmk, a caspase-9 inhibitor (Fig. 1 and 3). This evidence concerns the gene CASP1 and infection.