Reduction in levels of proinflammatory cytokines (IFN‐γ, TNF) with increase in anti‐inflammatory cytokines (IL‐4, IL‐10), with a shift from Th‐1 (proinflammatory) to Th‐2 (anti‐inflammatory) [227]Reduced salivary cortisol and IL‐6 [228]Increase in heart rate (HR) variabilityb [229, 230]Telomere Length (TL) was maintained (reduction in cancer patients) [216, 231]. The gene discussed is IL4; the disease is cancer.