The amyloid cascade hypothesis, postulated in 1992 by Hardy and Higgins, assumes that “Aβ disposition is a central event and causative agent of the AD pathogenic cascade and that tau tangles, cell loss, vascular damage, and dementia follow as a direct result of this disposition” (Hardy and Allsop 1991; Hardy and Higgins 1992). The gene discussed is MAPT; the disease is dementia.