Alzheimer's disease is characterized by the accumulation of cerebral plaques loaded with β‐amyloid peptide (Aβ) and dystrophic neuritis distributed throughout the cortical layer, as well as intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein in the medial temporal‐lobe structures (De Strooper and Karran 2016; Serrano‐Pozo et al. 2011). The gene discussed is MAPT; the disease is Alzheimer disease.