MAPT and Alzheimer disease: Other mutations were found in exons 9–13, with the resultant tau pathology varying in filamentous morphology and isoform composition according to the position and the nature of the mutation and resembling that of sporadic tauopathies such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), AD, or Pick's disease (PiD) (Goedert and Jakes 2005) (Figure 2).