Other therapeutic strategies have been investigated, and some have demonstrated beneficial effects in clinical trials through their anti‐inflammatory and neuroprotective effects, besides reducing the activity of BACE and γ‐secretases, such as non‐steroidal anti‐inflammatory drugs (NSAIDs), anti‐TNF‐α, Peroxisome proliferators activated receptor (PPARγ) agonists (Jiang et al. 2012) and recently, repeated menthol inhalation improved cognitive function of AD mice through its immunomodulatory mechanisms and downregulation of IL‐1β and IL‐6 mRNA in the prefrontal cortex (Casares et al. 2023). This evidence concerns the gene IL1B and Alzheimer disease.