Cattaneo's group was the first to provide evidence that neurotrophic deficits are the upstream driver by developing comprehensive AD‐like neurodegeneration in anti‐NGF ad11 mice (Cattaneo and Calissano 2012; Capsoni et al. 2000), which was reversed by early NGF delivery through an olfactory route (Capsoni et al. 2002). The gene discussed is NGF; the disease is Alzheimer disease.