The acetylcholinesterase inhibitors mediate their effects by partially alleviating the cholinergic deficit in AD (Deardorff et al. 2015), whereas the precise mechanism of action of memantine remains elusive, but it is thought to interfere with the neurotoxic effects of Aβ mediated on the NMDA receptor (Rogawski and Wenk 2003). This evidence concerns the gene ACHE and Alzheimer disease.