Recent studies have shown that ADM, as a marker of endothelial dysfunction, is rapidly induced in the initial stages of sepsis [13] and becomes extremely elevated when sepsis progresses to multiple organ failure [14]: in such a way, it represents a convenient biomarker for early identification of patients with severe infections progressing to multiple organ failure [15, 16, 17, 18, 19]. The gene discussed is ADM; the disease is Sepsis.