After tumor cell injury, ICD occurs, releasing multiple DAMPs with immunostimulatory properties, including IFN‐I, CRT, HMGB1, ATP, and HSP.[45] The DAMPs released following tumor cell ICD can promote the transition of M2‐type tumor associated macrophages (TAMs) to M1‐type in the distant tumor microenvironment. Here, HMGB1 is linked to neoplasm.