HMGB1 and neoplasm: In the CJP–TiN+L group, the expression levels of CD8+ T cells, HMGB1, and CXCL10 were significantly elevated in both the primary and distant tumor regions (Figures 7C–J), demonstrating that CJP–TiN+L treatment significantly enhanced T cell infiltration and chemokine expression, in addition to promoting macrophage polarization toward an antitumor phenotype.