Consistent with previous findings,10, 30 this study demonstrates that individuals with apoB levels exceeding a defined threshold, regardless of LDL‐C, non‐HDL‐C, or Lp(a) concentrations – exhibit a distinct risk factor profile, characterised by elevated triglycerides, reduced HDL‐C levels, and a significantly increased prevalence of hypertension, obesity, and diabetes. Here, APOB is linked to obesity due to melanocortin 4 receptor deficiency.