Both continuous apoB levels (HR per 1 mg/dL: 1.006, 95% CI: 1.002–1.010, p = .005) and apoB levels exceeding the threshold of 100 mg/dL (HR 1.431, 95% CI 1.106–1.852, p = .006) were significantly associated with increased risk of ASCVD over 20 years, after multivariable adjustment for demographic (age, sex), lifestyle (BMI, smoking status, physical activity, Mediterranean Diet adherence), and clinical factors (hypertension, diabetes, triglyceride levels, HDL‐C levels, family history of ASCVD). This evidence concerns the gene APOB and Hypertension.