The PAF of 20‐year ASCVD incidence was 20.3% (95% CI, 9.3–29.9) for apoB levels exceeding 100 mg/dL and 21.3% (95% CI, 11.7–28.9) for traditional modifiable risk factors (smoking, physical inactivity, hypertension, diabetes, obesity). The gene discussed is APOB; the disease is obesity due to melanocortin 4 receptor deficiency.