These additional putative mono/oligogenic SLE genes are involved in type I IFN regulation (DDX58, NLRC4 and PACSIN1), disruption of B cell and T cell tolerance (DOCK8, FAS and LRBA) and metabolic disorders (CYBB, MAN2B1, SLC7A7) (Figure 2). This evidence concerns the gene NLRC4 and metabolic disease.