To further probe whether some of the de novo variants occurring in genes not previously linked with SLE may contribute to disease, we selected two genes for functional analysis amongst the 12 genes that are both expressed most highly in ABCs/plasma cells and belong to the top 20 SLE pathways identified through enrichment analysis: DHX8 and ACTR5 (Figure 4C). Here, DHX8 is linked to systemic lupus erythematosus.