Our previous analyses in Caucasian SLE enriched in childhood/juvenile-onset disease identified 10 SLE-associated genes validated by eQTL analysis present in over 5% of SLE probands, with BLK, LYST, TYK2, UHRF1BP1 and IKBKE being the genes most commonly harboring rare variants25. This evidence concerns the gene TYK2 and systemic lupus erythematosus.