KDM6A and diabetic kidney disease: For example, UTX knockout restores the blood‒spinal cord barrier, reduces inflammatory infiltration, and ultimately promotes neurological recovery.[29] Additionally, UTX has been shown to enhance inflammation and DNA damage induced by palmitic acid, accelerating the progression of diabetic nephropathy.[30] However, the responsiveness of UTX/H3K27me3 to nanotopography and the molecular mechanisms by which they regulate macrophage inflammation remain unclear.