Specifically, trimethylation of histone H3 at lysine 27 (H3K27me3) serves as an important transcriptional repression marker that facilitates heterochromatin formation and establishes heritable gene silencing states.[20, 21, 22] UTX, a specific demethylase for H3K27me3, erases methylation at this site, and its dysfunction has been implicated in various pathophysiological processes, including abnormal embryonic development,[23, 24, 25] cellular senescence,[26] and tumor immune evasion.[25, 27, 28] Emerging evidence suggests that UTX is a central regulator of inflammatory cascades. Here, KDM6A is linked to neoplasm.