Without expression studies, clarification of these differential exploratory correlations is lacking, but the identified CpG genes have been associated with AD (PRRC2A, IL1RAPL1, RUBCN, and IVD), aging (TGM6), metabolic dysregulation (PLAAT5, GPR119, and PRRC2A), oxidative stress (HEPH and CAT), and inflammation (IL1RAPL1). This evidence concerns the gene RUBCN and Alzheimer disease.