Deficiency of the RANTES receptor CCR5 is associated with astrocyte activation, Aβ deposition, and impaired memory function (Lee et al., 2009; Hwang et al., 2016), and the nonfunctional human CCR5-delta32 polymorphism is associated with earlier dementia onset (Wojta et al., 2020). This evidence concerns the gene CCR5 and dementia.