For instance, the Wnt/β-catenin signaling pathway (67) and upregulating autophagy-related genes (Bcl-2, Beclin-1 and ATG-5) (Table 1) (68), have been implicated in RCC progression, and AIM2’s influence on these pathways could provide insights into its anti-tumor role (Figure 3, left panels). The gene discussed is AIM2; the disease is neoplasm.