MNDA interacts with chromatin and RNA polymerase II (Pol II) to control the transcription of genes such as IRF7, myeloid cell leukemia 1 (MCL1), and BCL2, enhancing type I IFN production (38) and promoting apoptosis in leukocytes and chronic lymphocytic leukemia (CLL) cells (6, 7). The gene discussed is IRF7; the disease is B-cell chronic lymphocytic leukemia.