CDKN1A and hepatocellular carcinoma: Delta-like 1 (DLK1) upregulated the expression of IFI16 and its promoter transcriptional activity, is accompanied by a decrease in p21WAF1/CIP1 levels and subsequent acceleration of the cell cycle, suggesting that IFI16 may serve as a pivotal downstream target of DLK1 in promoting HCC cell proliferation (Table 2) (141).