The phenotypic expression characterized by IFI16 negativity combined with Ki-67 positivity (IFI16-/Ki-67+) has been notably and positively correlated with advanced TNM staging in cancer patients, and it exhibits a borderline significant link to lymph node metastasis, as reported in a pivotal study (Table 2) (128, 129). The gene discussed is IFI16; the disease is metastatic malignant neoplasm in the lymph nodes.