IFI16 and neoplasm: Restoration of IFI16 levels in head and neck squamous cell carcinoma (HNSCC) exhibits potent antitumor effects by inhibiting tumor growth and in vitro transforming activity, as well as augmenting doxorubicin-induced cell death via the accumulation of cells at the G2/M phase (Figure 4, left panels and Table 2) (119).