found that Glutathione S-transferase α1 (GSTA1) was highly expressed in HCC drug resistance models, and GSTA1 could promote the entry of CTNNB1 in the cytoplasm into the nucleus and activate the transcriptional activity of GSTA1, promote the expression of GSTA1, and form a positive feedback loop. This evidence concerns the gene GSTA1 and hepatocellular carcinoma.