The combination of the ATO/PFH NPs@Au‐cRGD nano drug delivery system and anti-programmed cell death 1 (PD-L1) antibody can achieve synergistic treatment of HCC, which can effectively inhibit liver orthotopic tumors and lung metastases and can intuitively evaluate the treatment effect through visual imaging (87). The gene discussed is PDCD1; the disease is hepatocellular carcinoma.