CiteSpace was used to further analyze the keywords in the relevant literature, as shown in Figure 8C, eight tags were generated by keyword clustering, namely: cluster #0 “gastrointestinal cancer”, cluster #1 “methyladenosine modification”, cluster #2 “hepatocellular carcinoma cell”, cluster #3 “prognosis chemoresistance”, cluster #4 “liver diseases”, cluster #5 “ferroptosis-related gene”, cluster #6 “nano ultrasound contrast agent”, and cluster #7 “targeting usp8 inhibits o-glcnacylation”, they represent the current research hotspots and cutting-edge trends. Here, USP8 is linked to hepatocellular carcinoma.