found that IGF2BP3 read m6A modification to promote the stability of NRF2 mRNA from in vitro and in vivo experiments, further revealing that the IGF2BP3-NRF2 axis can affect ferritin deposition during the pathogenesis of HCC, thereby regulating ferroptosis, which provides the possibility of improving the sensitivity of hepatocellular carcinoma cells to sorafenib (66). This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.