Statistical differential gene expression analysis showed initial CPMV treatment of melanoma tumors downregulated several protumoral genes, including IL1B, PTGS2, CCL3, CCL4, EGR1, IL6, FLT3, THY1 (CD90), SDC4, COLEC12, PNMA1, and TXNIP by day 14. This evidence concerns the gene SDC4 and melanoma.