CD40LG and infection: Further intra-group analysis at 21 months stratified by infection status (N+ = infected, N− = uninfected) showed a trend toward higher IgM−/IgG+ MBCs induction in infected [N+] subjects compared to uninfected [N−] within the ChAd/BNT group, though this difference did not reach statistical significance (p = 0.0563) (Supplementary Figure S7A).