Significant correlations were identified between LRFN4 expression and immune cell infiltration across all 44 cancer types (39, 40), showing notable positive associations with certain immune cell types (e.g., MEP cells, MSC cells, Th1 cells, Th2 cells) and significant negative correlations with others (P < 0.05) (Figure 13A). Here, LRFN4 is linked to cancer.