Domain-specific changes, such as Q48*p of the fn3 domain (Figure 11B), were detected in isolated cases of lung adenocarcinoma (LUAD) and stomach adenocarcinoma (STAD), potentially leading to missense mutations in the LRFN4 gene, highlighting the diverse genetic landscapes associated with LRFN4 alterations. The gene discussed is LRFN4; the disease is lung adenocarcinoma.